SARS-CoV-2 Pneumonia in Hospitalized Asthmatic Patients Did Not Induce Severe Exacerbation.
Identifieur interne : 000691 ( Main/Exploration ); précédent : 000690; suivant : 000692SARS-CoV-2 Pneumonia in Hospitalized Asthmatic Patients Did Not Induce Severe Exacerbation.
Auteurs : Manon Grandbastien [France] ; Anays Piotin [France] ; Julien Godet [France] ; Ines Abessolo-Amougou [France] ; Carole Ederlé [France] ; Irina Enache [France] ; Philippe Fraisse [France] ; Thi Cam Tu Hoang [France] ; Loic Kassegne [France] ; Aissam Labani [France] ; Pierre Leyendecker [France] ; Louise Manien [France] ; Christophe Marcot [France] ; Guillaume Pamart [France] ; Benjamin Renaud-Picard [France] ; Marianne Riou [France] ; Virginie Doyen [Belgique] ; Romain Kessler [France] ; Samira Fafi-Kremer [France] ; Carine Metz-Favre [France] ; Naji Khayath [France] ; Frédéric De Blay [France]Source :
- The journal of allergy and clinical immunology. In practice [ 2213-2201 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Agonistes bêta-adrénergiques (usage thérapeutique), Asthme (physiopathologie), Asthme (traitement médicamenteux), Asthme (épidémiologie), Betacoronavirus (MeSH), Comorbidité (MeSH), Facteurs socioéconomiques (MeSH), Femelle (MeSH), Glucocorticoïdes (usage thérapeutique), Hospitalisation (statistiques et données numériques), Humains (MeSH), Indice de gravité de la maladie (MeSH), Infections à coronavirus (physiopathologie), Infections à coronavirus (épidémiologie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (physiopathologie), Pneumopathie virale (épidémiologie), Sujet âgé (MeSH), Unités de soins intensifs (MeSH), Ventilation artificielle (MeSH), Études rétrospectives (MeSH).
- MESH :
- physiopathologie : Asthme, Infections à coronavirus, Pneumopathie virale.
- statistiques et données numériques : Hospitalisation.
- traitement médicamenteux : Asthme.
- usage thérapeutique : Agonistes bêta-adrénergiques, Glucocorticoïdes.
- épidémiologie : Asthme, Infections à coronavirus, Pneumopathie virale.
- Adulte d'âge moyen, Betacoronavirus, Comorbidité, Facteurs socioéconomiques, Femelle, Humains, Indice de gravité de la maladie, Mâle, Pandémies, Sujet âgé, Unités de soins intensifs, Ventilation artificielle, Études rétrospectives.
English descriptors
- KwdEn :
- Adrenergic beta-Agonists (therapeutic use), Aged (MeSH), Asthma (drug therapy), Asthma (epidemiology), Asthma (physiopathology), Betacoronavirus (MeSH), Comorbidity (MeSH), Coronavirus Infections (epidemiology), Coronavirus Infections (physiopathology), Female (MeSH), Glucocorticoids (therapeutic use), Hospitalization (statistics & numerical data), Humans (MeSH), Intensive Care Units (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (epidemiology), Pneumonia, Viral (physiopathology), Respiration, Artificial (MeSH), Retrospective Studies (MeSH), Severity of Illness Index (MeSH), Socioeconomic Factors (MeSH).
- MESH :
- chemical , therapeutic use : Adrenergic beta-Agonists, Glucocorticoids.
- drug therapy : Asthma.
- epidemiology : Asthma, Coronavirus Infections, Pneumonia, Viral.
- physiopathology : Asthma, Coronavirus Infections, Pneumonia, Viral.
- statistics & numerical data : Hospitalization.
- Aged, Betacoronavirus, Comorbidity, Female, Humans, Intensive Care Units, Male, Middle Aged, Pandemics, Respiration, Artificial, Retrospective Studies, Severity of Illness Index, Socioeconomic Factors.
Abstract
BACKGROUND
Viral infections are known to exacerbate asthma in adults. Previous studies have found few patients with asthma among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia cases. However, the relationship between SARS-CoV-2 infection and severe asthma exacerbation is not known.
OBJECTIVE
To assess the frequency of asthma exacerbation in patients with asthma hospitalized for SARS-CoV-2 pneumonia and compare symptoms and laboratory and radiological findings in patients with and without asthma with SARS-CoV-2 pneumonia.
METHODS
We included 106 patients between March 4 and April 6, 2020, who were hospitalized in the Chest Diseases Department of Strasbourg University Hospital; 23 had asthma. To assess the patients' asthma status, 3 periods were defined: the last month before the onset of COVID-19 symptoms (p1), prehospitalization (p2), and during hospitalization (p3). Severe asthma exacerbations were defined according to Global INitiative for Asthma guidelines during p1 and p2. During p3, we defined severe asthma deterioration as the onset of breathlessness and wheezing requiring systemic corticosteroids and inhaled β2 agonist.
RESULTS
We found no significant difference between patients with and without asthma in terms of severity (length of stay, maximal oxygen flow needed, noninvasive ventilation requirement, and intensive care unit transfer); 52.2% of the patients with asthma had Global INitiative for Asthma step 1 asthma. One patient had a severe exacerbation during p1, 2 patients during p2, and 5 patients were treated with systemic corticosteroids and inhaled β2 agonist during p3.
CONCLUSIONS
Our results demonstrate that patients with asthma appeared not to be at risk for severe SARS-CoV-2 pneumonia. Moreover, SARS-CoV-2 pneumonia did not induce severe asthma exacerbation.
DOI: 10.1016/j.jaip.2020.06.032
PubMed: 32603901
PubMed Central: PMC7320869
Affiliations:
- Belgique, France
- Alsace (région administrative), Grand Est, Région de Bruxelles-Capitale
- Bruxelles, Strasbourg
Links toward previous steps (curation, corpus...)
Le document en format XML
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type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Riou, Marianne" sort="Riou, Marianne" uniqKey="Riou M" first="Marianne" last="Riou">Marianne Riou</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Doyen, Virginie" sort="Doyen, Virginie" uniqKey="Doyen V" first="Virginie" last="Doyen">Virginie Doyen</name><affiliation wicri:level="3"><nlm:affiliation>Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Kessler, Romain" sort="Kessler, Romain" uniqKey="Kessler R" first="Romain" last="Kessler">Romain Kessler</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France; Department of Radiology B, Strasbourg University Hospital, Strasbourg, France; Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels, Belgium; INSERM-UNISTRA, UMR 1260 "Regenerative NanoMedecine," University of Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France; Department of Radiology B, Strasbourg University Hospital, Strasbourg, France; Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels, Belgium; INSERM-UNISTRA, UMR 1260 "Regenerative NanoMedecine," University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Fafi Kremer, Samira" sort="Fafi Kremer, Samira" uniqKey="Fafi Kremer S" first="Samira" last="Fafi-Kremer">Samira Fafi-Kremer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Virology, Strasbourg University Hospital, INSERM U748, University of Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Virology, Strasbourg University Hospital, INSERM U748, University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Metz Favre, Carine" sort="Metz Favre, Carine" uniqKey="Metz Favre C" first="Carine" last="Metz-Favre">Carine Metz-Favre</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Khayath, Naji" sort="Khayath, Naji" uniqKey="Khayath N" first="Naji" last="Khayath">Naji Khayath</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="De Blay, Frederic" sort="De Blay, Frederic" uniqKey="De Blay F" first="Frédéric" last="De Blay">Frédéric De Blay</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France. Electronic address: frederic.deblay@chru-strasbourg.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32603901</idno><idno type="pmid">32603901</idno><idno type="doi">10.1016/j.jaip.2020.06.032</idno><idno type="pmc">PMC7320869</idno><idno type="wicri:Area/Main/Corpus">000B55</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000B55</idno><idno type="wicri:Area/Main/Curation">000B55</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000B55</idno><idno type="wicri:Area/Main/Exploration">000B55</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">SARS-CoV-2 Pneumonia in Hospitalized Asthmatic Patients Did Not Induce Severe Exacerbation.</title><author><name sortKey="Grandbastien, Manon" sort="Grandbastien, Manon" uniqKey="Grandbastien M" first="Manon" last="Grandbastien">Manon Grandbastien</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Piotin, Anays" sort="Piotin, Anays" uniqKey="Piotin A" first="Anays" last="Piotin">Anays Piotin</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Godet, Julien" sort="Godet, Julien" uniqKey="Godet J" first="Julien" last="Godet">Julien Godet</name><affiliation wicri:level="3"><nlm:affiliation>Public Health Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Public Health Department, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Abessolo Amougou, Ines" sort="Abessolo Amougou, Ines" uniqKey="Abessolo Amougou I" first="Ines" last="Abessolo-Amougou">Ines Abessolo-Amougou</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Ederle, Carole" sort="Ederle, Carole" uniqKey="Ederle C" first="Carole" last="Ederlé">Carole Ederlé</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Enache, Irina" sort="Enache, Irina" uniqKey="Enache I" first="Irina" last="Enache">Irina Enache</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Fraisse, Philippe" sort="Fraisse, Philippe" uniqKey="Fraisse P" first="Philippe" last="Fraisse">Philippe Fraisse</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Tu Hoang, Thi Cam" sort="Tu Hoang, Thi Cam" uniqKey="Tu Hoang T" first="Thi Cam" last="Tu Hoang">Thi Cam Tu Hoang</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Kassegne, Loic" sort="Kassegne, Loic" uniqKey="Kassegne L" first="Loic" last="Kassegne">Loic Kassegne</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Labani, Aissam" sort="Labani, Aissam" uniqKey="Labani A" first="Aissam" last="Labani">Aissam Labani</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiology B, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Radiology B, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Leyendecker, Pierre" sort="Leyendecker, Pierre" uniqKey="Leyendecker P" first="Pierre" last="Leyendecker">Pierre Leyendecker</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiology B, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Radiology B, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Manien, Louise" sort="Manien, Louise" uniqKey="Manien L" first="Louise" last="Manien">Louise Manien</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Marcot, Christophe" sort="Marcot, Christophe" uniqKey="Marcot C" first="Christophe" last="Marcot">Christophe Marcot</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Pamart, Guillaume" sort="Pamart, Guillaume" uniqKey="Pamart G" first="Guillaume" last="Pamart">Guillaume Pamart</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Renaud Picard, Benjamin" sort="Renaud Picard, Benjamin" uniqKey="Renaud Picard B" first="Benjamin" last="Renaud-Picard">Benjamin Renaud-Picard</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Riou, Marianne" sort="Riou, Marianne" uniqKey="Riou M" first="Marianne" last="Riou">Marianne Riou</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Doyen, Virginie" sort="Doyen, Virginie" uniqKey="Doyen V" first="Virginie" last="Doyen">Virginie Doyen</name><affiliation wicri:level="3"><nlm:affiliation>Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Kessler, Romain" sort="Kessler, Romain" uniqKey="Kessler R" first="Romain" last="Kessler">Romain Kessler</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France; Department of Radiology B, Strasbourg University Hospital, Strasbourg, France; Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels, Belgium; INSERM-UNISTRA, UMR 1260 "Regenerative NanoMedecine," University of Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France; Department of Radiology B, Strasbourg University Hospital, Strasbourg, France; Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels, Belgium; INSERM-UNISTRA, UMR 1260 "Regenerative NanoMedecine," University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Fafi Kremer, Samira" sort="Fafi Kremer, Samira" uniqKey="Fafi Kremer S" first="Samira" last="Fafi-Kremer">Samira Fafi-Kremer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Virology, Strasbourg University Hospital, INSERM U748, University of Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Virology, Strasbourg University Hospital, INSERM U748, University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Metz Favre, Carine" sort="Metz Favre, Carine" uniqKey="Metz Favre C" first="Carine" last="Metz-Favre">Carine Metz-Favre</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Khayath, Naji" sort="Khayath, Naji" uniqKey="Khayath N" first="Naji" last="Khayath">Naji Khayath</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="De Blay, Frederic" sort="De Blay, Frederic" uniqKey="De Blay F" first="Frédéric" last="De Blay">Frédéric De Blay</name><affiliation wicri:level="3"><nlm:affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France. Electronic address: frederic.deblay@chru-strasbourg.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author></analytic><series><title level="j">The journal of allergy and clinical immunology. In practice</title><idno type="eISSN">2213-2201</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenergic beta-Agonists (therapeutic use)</term><term>Aged (MeSH)</term><term>Asthma (drug therapy)</term><term>Asthma (epidemiology)</term><term>Asthma (physiopathology)</term><term>Betacoronavirus (MeSH)</term><term>Comorbidity (MeSH)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (physiopathology)</term><term>Female (MeSH)</term><term>Glucocorticoids (therapeutic use)</term><term>Hospitalization (statistics & numerical data)</term><term>Humans (MeSH)</term><term>Intensive Care Units (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (physiopathology)</term><term>Respiration, Artificial (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Severity of Illness Index (MeSH)</term><term>Socioeconomic Factors (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Agonistes bêta-adrénergiques (usage thérapeutique)</term><term>Asthme (physiopathologie)</term><term>Asthme (traitement médicamenteux)</term><term>Asthme (épidémiologie)</term><term>Betacoronavirus (MeSH)</term><term>Comorbidité (MeSH)</term><term>Facteurs socioéconomiques (MeSH)</term><term>Femelle (MeSH)</term><term>Glucocorticoïdes (usage thérapeutique)</term><term>Hospitalisation (statistiques et données numériques)</term><term>Humains (MeSH)</term><term>Indice de gravité de la maladie (MeSH)</term><term>Infections à coronavirus (physiopathologie)</term><term>Infections à coronavirus (épidémiologie)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (physiopathologie)</term><term>Pneumopathie virale (épidémiologie)</term><term>Sujet âgé (MeSH)</term><term>Unités de soins intensifs (MeSH)</term><term>Ventilation artificielle (MeSH)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenergic beta-Agonists</term><term>Glucocorticoids</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Asthma</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Asthma</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Asthme</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Asthma</term><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Hospitalisation</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Asthme</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agonistes bêta-adrénergiques</term><term>Glucocorticoïdes</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Asthme</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Betacoronavirus</term><term>Comorbidity</term><term>Female</term><term>Humans</term><term>Intensive Care Units</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Respiration, Artificial</term><term>Retrospective Studies</term><term>Severity of Illness Index</term><term>Socioeconomic Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Betacoronavirus</term><term>Comorbidité</term><term>Facteurs socioéconomiques</term><term>Femelle</term><term>Humains</term><term>Indice de gravité de la maladie</term><term>Mâle</term><term>Pandémies</term><term>Sujet âgé</term><term>Unités de soins intensifs</term><term>Ventilation artificielle</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Viral infections are known to exacerbate asthma in adults. Previous studies have found few patients with asthma among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia cases. However, the relationship between SARS-CoV-2 infection and severe asthma exacerbation is not known.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To assess the frequency of asthma exacerbation in patients with asthma hospitalized for SARS-CoV-2 pneumonia and compare symptoms and laboratory and radiological findings in patients with and without asthma with SARS-CoV-2 pneumonia.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We included 106 patients between March 4 and April 6, 2020, who were hospitalized in the Chest Diseases Department of Strasbourg University Hospital; 23 had asthma. To assess the patients' asthma status, 3 periods were defined: the last month before the onset of COVID-19 symptoms (p1), prehospitalization (p2), and during hospitalization (p3). Severe asthma exacerbations were defined according to Global INitiative for Asthma guidelines during p1 and p2. During p3, we defined severe asthma deterioration as the onset of breathlessness and wheezing requiring systemic corticosteroids and inhaled β2 agonist.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>We found no significant difference between patients with and without asthma in terms of severity (length of stay, maximal oxygen flow needed, noninvasive ventilation requirement, and intensive care unit transfer); 52.2% of the patients with asthma had Global INitiative for Asthma step 1 asthma. One patient had a severe exacerbation during p1, 2 patients during p2, and 5 patients were treated with systemic corticosteroids and inhaled β2 agonist during p3.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Our results demonstrate that patients with asthma appeared not to be at risk for severe SARS-CoV-2 pneumonia. Moreover, SARS-CoV-2 pneumonia did not induce severe asthma exacerbation.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32603901</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>17</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2213-2201</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>8</Issue><PubDate><Year>2020</Year><Month>Sep</Month></PubDate></JournalIssue><Title>The journal of allergy and clinical immunology. In practice</Title><ISOAbbreviation>J Allergy Clin Immunol Pract</ISOAbbreviation></Journal><ArticleTitle>SARS-CoV-2 Pneumonia in Hospitalized Asthmatic Patients Did Not Induce Severe Exacerbation.</ArticleTitle><Pagination><MedlinePgn>2600-2607</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S2213-2198(20)30667-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jaip.2020.06.032</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Viral infections are known to exacerbate asthma in adults. Previous studies have found few patients with asthma among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia cases. However, the relationship between SARS-CoV-2 infection and severe asthma exacerbation is not known.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To assess the frequency of asthma exacerbation in patients with asthma hospitalized for SARS-CoV-2 pneumonia and compare symptoms and laboratory and radiological findings in patients with and without asthma with SARS-CoV-2 pneumonia.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We included 106 patients between March 4 and April 6, 2020, who were hospitalized in the Chest Diseases Department of Strasbourg University Hospital; 23 had asthma. To assess the patients' asthma status, 3 periods were defined: the last month before the onset of COVID-19 symptoms (p1), prehospitalization (p2), and during hospitalization (p3). Severe asthma exacerbations were defined according to Global INitiative for Asthma guidelines during p1 and p2. During p3, we defined severe asthma deterioration as the onset of breathlessness and wheezing requiring systemic corticosteroids and inhaled β2 agonist.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We found no significant difference between patients with and without asthma in terms of severity (length of stay, maximal oxygen flow needed, noninvasive ventilation requirement, and intensive care unit transfer); 52.2% of the patients with asthma had Global INitiative for Asthma step 1 asthma. One patient had a severe exacerbation during p1, 2 patients during p2, and 5 patients were treated with systemic corticosteroids and inhaled β2 agonist during p3.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our results demonstrate that patients with asthma appeared not to be at risk for severe SARS-CoV-2 pneumonia. Moreover, SARS-CoV-2 pneumonia did not induce severe asthma exacerbation.</AbstractText><CopyrightInformation>Copyright © 2020 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Grandbastien</LastName><ForeName>Manon</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Piotin</LastName><ForeName>Anays</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Godet</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Public Health Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abessolo-Amougou</LastName><ForeName>Ines</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ederlé</LastName><ForeName>Carole</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Enache</LastName><ForeName>Irina</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fraisse</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tu Hoang</LastName><ForeName>Thi Cam</ForeName><Initials>TC</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kassegne</LastName><ForeName>Loic</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Labani</LastName><ForeName>Aissam</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Radiology B, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leyendecker</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Radiology B, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manien</LastName><ForeName>Louise</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marcot</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pamart</LastName><ForeName>Guillaume</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Renaud-Picard</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riou</LastName><ForeName>Marianne</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Doyen</LastName><ForeName>Virginie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kessler</LastName><ForeName>Romain</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France; Department of Radiology B, Strasbourg University Hospital, Strasbourg, France; Clinic of Immuno-Allergology, Brugmann Hospital, ULB, Brussels, Belgium; INSERM-UNISTRA, UMR 1260 "Regenerative NanoMedecine," University of Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fafi-Kremer</LastName><ForeName>Samira</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Virology, Strasbourg University Hospital, INSERM U748, University of Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Metz-Favre</LastName><ForeName>Carine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khayath</LastName><ForeName>Naji</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Blay</LastName><ForeName>Frédéric</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France; Public Health Department, Strasbourg University Hospital, Strasbourg, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, Strasbourg, France. Electronic address: frederic.deblay@chru-strasbourg.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Allergy Clin Immunol Pract</MedlineTA><NlmUniqueID>101597220</NlmUniqueID></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000318">Adrenergic beta-Agonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005938">Glucocorticoids</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000318" MajorTopicYN="N">Adrenergic beta-Agonists</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001249" MajorTopicYN="N">Asthma</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005938" MajorTopicYN="N">Glucocorticoids</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012959" MajorTopicYN="N">Socioeconomic Factors</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Asthma</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Coronavirus</Keyword><Keyword MajorTopicYN="N">Europe</Keyword><Keyword MajorTopicYN="N">Exacerbation</Keyword><Keyword MajorTopicYN="N">France</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2 pneumonia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>06</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32603901</ArticleId><ArticleId IdType="pii">S2213-2198(20)30667-X</ArticleId><ArticleId IdType="doi">10.1016/j.jaip.2020.06.032</ArticleId><ArticleId IdType="pmc">PMC7320869</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Belgique</li><li>France</li></country><region><li>Alsace (région administrative)</li><li>Grand Est</li><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li><li>Strasbourg</li></settlement></list><tree><country name="France"><region name="Grand Est"><name sortKey="Grandbastien, Manon" sort="Grandbastien, Manon" uniqKey="Grandbastien M" first="Manon" last="Grandbastien">Manon Grandbastien</name></region><name sortKey="Abessolo Amougou, Ines" sort="Abessolo Amougou, Ines" uniqKey="Abessolo Amougou I" first="Ines" last="Abessolo-Amougou">Ines Abessolo-Amougou</name><name sortKey="De Blay, Frederic" sort="De Blay, Frederic" uniqKey="De Blay F" first="Frédéric" last="De Blay">Frédéric De Blay</name><name sortKey="Ederle, Carole" sort="Ederle, Carole" uniqKey="Ederle C" first="Carole" last="Ederlé">Carole Ederlé</name><name sortKey="Enache, Irina" sort="Enache, Irina" uniqKey="Enache I" first="Irina" last="Enache">Irina Enache</name><name sortKey="Fafi Kremer, Samira" sort="Fafi Kremer, Samira" uniqKey="Fafi Kremer S" first="Samira" last="Fafi-Kremer">Samira Fafi-Kremer</name><name sortKey="Fraisse, Philippe" sort="Fraisse, Philippe" uniqKey="Fraisse P" first="Philippe" last="Fraisse">Philippe Fraisse</name><name sortKey="Godet, Julien" sort="Godet, Julien" uniqKey="Godet J" first="Julien" last="Godet">Julien Godet</name><name sortKey="Kassegne, Loic" sort="Kassegne, Loic" uniqKey="Kassegne L" first="Loic" last="Kassegne">Loic Kassegne</name><name sortKey="Kessler, Romain" sort="Kessler, Romain" uniqKey="Kessler R" first="Romain" last="Kessler">Romain Kessler</name><name sortKey="Khayath, Naji" sort="Khayath, Naji" uniqKey="Khayath N" first="Naji" last="Khayath">Naji Khayath</name><name sortKey="Labani, Aissam" sort="Labani, Aissam" uniqKey="Labani A" first="Aissam" last="Labani">Aissam Labani</name><name sortKey="Leyendecker, Pierre" sort="Leyendecker, Pierre" uniqKey="Leyendecker P" first="Pierre" last="Leyendecker">Pierre Leyendecker</name><name sortKey="Manien, Louise" sort="Manien, Louise" uniqKey="Manien L" first="Louise" last="Manien">Louise Manien</name><name sortKey="Marcot, Christophe" sort="Marcot, Christophe" uniqKey="Marcot C" first="Christophe" last="Marcot">Christophe Marcot</name><name sortKey="Metz Favre, Carine" sort="Metz Favre, Carine" uniqKey="Metz Favre C" first="Carine" last="Metz-Favre">Carine Metz-Favre</name><name sortKey="Pamart, Guillaume" sort="Pamart, Guillaume" uniqKey="Pamart G" first="Guillaume" last="Pamart">Guillaume Pamart</name><name sortKey="Piotin, Anays" sort="Piotin, Anays" uniqKey="Piotin A" first="Anays" last="Piotin">Anays Piotin</name><name sortKey="Renaud Picard, Benjamin" sort="Renaud Picard, Benjamin" uniqKey="Renaud Picard B" first="Benjamin" last="Renaud-Picard">Benjamin Renaud-Picard</name><name sortKey="Riou, Marianne" sort="Riou, Marianne" uniqKey="Riou M" first="Marianne" last="Riou">Marianne Riou</name><name sortKey="Tu Hoang, Thi Cam" sort="Tu Hoang, Thi Cam" uniqKey="Tu Hoang T" first="Thi Cam" last="Tu Hoang">Thi Cam Tu Hoang</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Doyen, Virginie" sort="Doyen, Virginie" uniqKey="Doyen V" first="Virginie" last="Doyen">Virginie Doyen</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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